免疫原
Synthesized peptide derived from human protein . at AA range: 1430-1510
特异性
MLL2 Polyclonal Antibody detects endogenous levels of protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
IHC-p 1:50-300. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The protein encoded by this gene is a histone methyltransferase that methylates the Lys-4 position of histone H3. The encoded protein is part of a large protein complex called ASCOM, which has been shown to be a transcriptional regulator of the beta-globin and estrogen receptor genes. Mutations in this gene have been shown to be a cause of Kabuki syndrome. [provided by RefSeq, Oct 2010],
功能
catalytic activity:S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.,domain:LXXLL motifs 5 and 5 are essential for the association with ESR1 nuclear receptor.,function:Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription.,miscellaneous:This gene mapped to a chromosomal region involved in duplications and translocations associated with cancer.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily.,similarity:Contains 1 post-SET domain.,similarity:Contai
基因名称（Gene Name）
MLL2 ALR KMT2D MLL4
蛋白名称
Histone-lysine N-methyltransferase MLL2 (EC 2.1.1.43) (ALL1-related protein) (Lysine N-methyltransferase 2D) (KMT2D) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)
Fields
>>Lysine degradation;>>Metabolic pathways;>>Cushing syndrome
组织表达
Expressed in most adult tissues, including a variety of hematoipoietic cells, with the exception of the liver.
联系我们
关注我们
您当前的位置： 
说明书
成功添加到购物车
