免疫原
Synthesized peptide derived from human protein . at AA range: 470-550
特异性
MRP5 Polyclonal Antibody detects endogenous levels of protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
WB 1:500-2000 ELISA 1:5000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside
功能
function:Acts as a multispecific organic anion pump which can transport nucleotide analogs.,similarity:Belongs to the ABC transporter family.,similarity:Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamily.,similarity:Contains 2 ABC transmembrane type-1 domains.,similarity:Contains 2 ABC transporter domains.,
基因名称（Gene Name）
ABCC5 MRP5
蛋白名称
Multidrug resistance-associated protein 5 (ATP-binding cassette sub-family C member 5) (Multi-specific organic anion transporter C) (MOAT-C) (SMRP) (pABC11)
Fields
>>Antifolate resistance;>>ABC transporters
细胞定位
Basolateral cell membrane ; Multi-pass membrane protein . Golgi apparatus lumen . Endosome membrane . Cytoplasmic granule . Apical cell membrane ; Multi-pass membrane protein . In most cells, routes to the basolateral plasma membrane, but in the brain capillary endothelial cells that form the blood-brain barrier, resides in the apical membrane. .
组织表达
[Isoform 3]: Predominant isoform in retinal pigment epithelium, bladder, and stomach. ; Ubiquitously expressed, but levels in brain and muscle are especially high (PubMed:9827529, PubMed:10438534, PubMed:15501592). All isoforms are equally expressed in retina (PubMed:17521428).
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