免疫原
Synthesized peptide derived from human protein . at AA range: 70-150
特异性
MSX1 Polyclonal Antibody detects endogenous levels of protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
WB 1:500-2000 ELISA 1:5000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a member of the muscle segment homeobox gene family. The encoded protein functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. It may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations in this gene, which was once known as homeobox 7, have been associated with nonsyndromic cleft lip with or without cleft palate 5, Witkop syndrome, Wolf-Hirschom syndrome, and autosomoal dominant hypodontia. [provided by RefSeq, Jul 2008],
功能
disease:A chromosomal aberration involving MSX1 is a cause of Wolf-Hirschhorn syndrome (WHS) [MIM:194190]. WHS is caused by sub-telomeric deletions in the short arm of chromosome 4. WHS is characterized by profound mental retardation, heart defects, and facial clefting.,disease:Defects in MSX1 are a cause of autosomal dominant hypodontia (HYD1) [MIM:106600]; also known as familial or selective tooth agenesis. Absence of less than 6 teeth is referred to as hypodontia. Agenesis of one or more teeth constitutes one of the most common developmental anomalies in man. Reported incidences vary from 1.6% to 9.6%, excluding third molar (Wisdom tooth) agenesis, which occurs in 20% of the population.,disease:Defects in MSX1 are the cause of non-syndromic orofacial cleft type 5 (OFC5) [MIM:608874]; also called non-syndromic cleft lip with or without cleft palate 5. Non-syndromic orofacial cleft is a
基因名称（Gene Name）
MSX1 HOX7
蛋白名称
Homeobox protein MSX-1 (Homeobox protein Hox-7) (Msh homeobox 1-like protein)
Fields
>>Human T-cell leukemia virus 1 infection
组织表达
Expressed in the developing nail bed mesenchyme.
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