免疫原
The antiserum was produced against synthesized peptide derived from the C-terminal region of human DKK1. AA range:181-230
特异性
Dkk-1 Polyclonal Antibody detects endogenous levels of Dkk-1 protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq, Jul 2008],
功能
function:Inhibitor of Wnt signaling pathway.,similarity:Belongs to the dickkopf family.,tissue specificity:Placenta.,
蛋白名称
Dickkopf-related protein 1
其他名称
DKK1; Dickkopf-related protein 1; Dickkopf-1; Dkk-1; hDkk-1; SK
Fields
>>Wnt signaling pathway;>>Alzheimer disease;>>Pathways of neurodegeneration - multiple diseases
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