免疫原
The antiserum was produced against synthesized peptide derived from human PARD6B. AA range:233-282
特异性
PAR-6β Polyclonal Antibody detects endogenous levels of PAR-6β protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. [provided by RefSeq, Jul 2008],
功能
domain:The PDZ domain mediates interaction with MPP5.,domain:The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.,function:Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.,similarity:Belongs to the PAR6 family.,similarity:Contains 1 OPR domain.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 pseudo-CRIB domain.,subunit:Interacts with PARD3. Interacts with GTP-bound forms of CDC42 and RAC1. Interacts with GTP-bound ARHQ/TC10. Interacts with MPP5 (By similarity). Interacts with the N-terminal part of PRKCI and
蛋白名称
Partitioning defective 6 homolog beta
其他名称
PARD6B; PAR6B; Partitioning defective 6 homolog beta; PAR-6 beta; PAR-6B
Fields
>>Rap1 signaling pathway;>>Endocytosis;>>Axon guidance;>>Hippo signaling pathway;>>Tight junction;>>Human papillomavirus infection
细胞定位
Cytoplasm. Cell membrane . Cell junction, tight junction .
组织表达
Expressed in pancreas and in both adult and fetal kidney. Weakly expressed in placenta and lung. Not expressed in other tissues.
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