免疫原
The antiserum was produced against synthesized peptide derived from human CEP35. AA range:671-720
特异性
CEP350 Polyclonal Antibody detects endogenous levels of CEP350 protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
centrosomal protein 350(CEP350) Homo sapiens The product of this gene is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. The encoded protein primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. The encoded protein directly interacts with another large centrosomal protein and is required to anchor microtubules at the centrosome. It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008],
功能
function:Required for anchoring microtubules to the centrosomes. Required for the integrity of the microtubule network. Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity.,PTM:Phosphorylated during mitosis.,similarity:Contains 1 CAP-Gly domain.,subcellular location:Associated with mitotic spindles. Nuclear, in discrete foci. Associated with intermediate filaments.,subunit:Part of a ternary complex that contains CEP350, FGFR1OP and MAPRE1. Interacts directly with FGFR1OP via its C-terminus. Interacts with NR1H3, PPARA, PPARD and PPARG.,tissue specificity:Detected in heart, brain, skeletal muscle, testis, placenta, lung, liver, kidney and pancreas.,
蛋白名称
Centrosome-associated protein 350
其他名称
CEP350; CAP350; KIAA0480; GM133; Centrosome-associated protein 350; Cep350; Centrosome-associated protein of 350 kDa
细胞定位
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle . Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm, cytoskeleton, cilium basal body . Associated with mitotic spindles (PubMed:16314388). Nuclear, in discrete foci. Associated with intermediate filaments (PubMed:15615782). Also present in the pericentrosomal area (PubMed:17878239). Localizes on both mother and daughter centrioles. Localizes to an axial position on the mother centriole (PubMed:28625565). Localizes to the distal end of the centriole on the subdistal appendage region (PubMed:28659385). .
组织表达
Detected in heart, brain, skeletal muscle, testis, placenta, lung, liver, kidney and pancreas.
联系我们
关注我们
您当前的位置： 
说明书
成功添加到购物车
