欢迎访问南京博研生物官网 服务热线:025-52298998 |
您当前的位置: 首页 > 产品中心 > 一抗 > 单克隆抗体

TBLR1 mouse mAb

说明书

BYab-03267

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

产品简介 实验方案 引用文献 相关产品

产品简介>

宿主
反应性
应用
WB;IHC;ICC
分子量(DA)
60kD
免疫原
Purified recombinant human TBLR1 protein fragments expressed in E.coli.
特异性
This antibody detects endogenous levels of TBLR1 and does not cross-react with related proteins.
来源
Monoclonal, Mouse
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
wb 1:1000 icc 1:200 1:500-1:1000
纯化工艺(Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
浓度
1 mg/ml
背景(Background)
This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors. [provided by RefSeq, Mar 2016],
功能
domain:The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes.,function:F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteosomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the WD repeat EBI family.,similarity:Contains 1 F-box-like domain.,similarity:Contains 1 LisH domain.,simi
基因名称(Gene Name)
tbl1xr1
蛋白名称
简称
TBLR1
其他名称
C21;DC42;F box like/WD repeat containing protein TBL1XR1;F-box-like/WD repeat-containing protein TBL1XR1;FLJ12894;IRA1;Nuclear receptor corepressor/HDAC3 complex subunit;Nuclear receptor corepressor/HDAC3 complex subunit TBLR1;TBL1 related protein 1;TBL1-related protein 1;TBL1R_HUMAN;TBL1XR1;Transducin (beta) like 1 X linked receptor 1;Transducin beta like 1X related protein 1;Transducin beta-like 1X-related protein 1.
Fields
>>Wnt signaling pathway
人基因ID
79718
人蛋白质序列数据库
Q9BZK7
小鼠基因ID
小鼠蛋白质序列数据库
Q8BHJ5
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Nucleus .
组织表达
Widely expressed including the pituitary, hypothalamus, white and brown adipose tissue, muscle and liver.
储存(Storage)
-20°C/1 year

实验方案>

实验步骤

引用文献(0)>

相关产品>

成功添加到购物车

查看购物车 继续购物

TBLR1 mouse mAb

筛选器: All

亮暗模式切换
X

在线
客服

在线客服
09:00 - 18:00

服务热线

服务
热线

客服服务热线

025-52298998
客服服务热线

扫码

扫码
咨询

微信二维码 微信扫一扫立即咨询
返回顶部 顶部