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LysRS Monoclonal Antibody

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BYab-00999

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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宿主
反应性
应用
WB;IHC;IF;ELISA
分子量(DA)
免疫原
Purified recombinant fragment of LysRS(aa90-174) expressed in E. Coli.
特异性
LysRS Monoclonal Antibody detects endogenous levels of LysRS protein.
来源
Monoclonal, Mouse
组成(Formulation)
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
稀释比例
WB: 1/500 - 1/2000. IHC: 1/200 - 1/1000. ELISA: 1/10000.. IF 1:50-200
纯化工艺(Immunogen)
Affinity purification
浓度
背景(Background)
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
功能
catalytic activity:ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).,similarity:Belongs to the class-II aminoacyl-tRNA synthetase family.,subunit:Homodimer (By similarity); also part of a multisubunit complex that groups tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu, Lys, Met and Pro.,
基因名称(Gene Name)
KARS
蛋白名称
Lysyl-tRNA synthetase
简称
LysRS
其他名称
KARS; KIAA0070; Lysine--tRNA ligase; Lysyl-tRNA synthetase; LysRS
Fields
>>Aminoacyl-tRNA biosynthesis
人基因ID
3735
人蛋白质序列数据库
Q15046
小鼠基因ID
小鼠蛋白质序列数据库
Q99MN1
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
[Isoform Cytoplasmic]: Cytoplasm, cytosol . Cytoplasm . Nucleus . Cell membrane ; Peripheral membrane protein . Secreted . Secretion is induced by TNF-alpha (PubMed:15851690). Cytosolic in quiescent mast cells. Translocates into the nucleus in response to mast cell activation by immunoglobulin E (PubMed:23159739). .; [Isoform Mitochondrial]: Mitochondrion .
组织表达
Bone marrow,Brain,Cerebellum,Hepatoma,Placenta,
储存(Storage)
-20°C/1 year

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LysRS Monoclonal Antibody

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