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FoxP3 Monoclonal Antibody

说明书

BYab-00981

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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宿主
反应性
应用
WB;IHC;IF;ELISA
分子量(DA)
免疫原
Purified recombinant fragment of human FoxP3 expressed in E. Coli.
特异性
FoxP3 Monoclonal Antibody detects endogenous levels of FoxP3 protein.
来源
Monoclonal, Mouse
组成(Formulation)
Purified antibody in PBS containing 0.03% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
纯化工艺(Immunogen)
Affinity purification
浓度
1 mg/ml
背景(Background)
The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],
功能
disease:Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) [MIM:304790]; also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema. It is usually lethal in infancy.,function:Probable transcription factor. Plays a critical role in the control of immune response.,online information:FOXP3 entry,online information:FOXP3 mutation db,similarity:Contains 1 C2H2-type zinc finger.,similarity:Contains 1 fork-head DNA-binding domain.,
基因名称(Gene Name)
FOXP3
蛋白名称
Forkhead box protein P3
简称
FoxP3
其他名称
FOXP3; IPEX; JM2; Forkhead box protein P3; Scurfin
Fields
>>Th17 cell differentiation;>>Inflammatory bowel disease
人基因ID
50943
人蛋白质序列数据库
Q9BZS1
小鼠基因ID
20371
小鼠蛋白质序列数据库
Q99JB6
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Nucleus . Cytoplasm . Predominantly expressed in the cytoplasm in activated conventional T-cells whereas predominantly expressed in the nucleus in regulatory T-cells (Treg). The 41 kDa form derived by proteolytic processing is found exclusively in the chromatin fraction of activated Treg cells (By similarity). .
组织表达
储存(Storage)
-20°C/1 year

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FoxP3 Monoclonal Antibody

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