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HMGN1/2/3/4 (Acetyl Lys27/K33/K31) rabbit pAb

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BYab-00909

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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宿主
反应性
应用
WB; ELISA
分子量(DA)
12kD
免疫原
Synthesized peptide derived from human HMGN1/2/3/4 (Acetyl Lys27/K33/K31)
特异性
This antibody detects endogenous levels of Human,Mouse,Rat HMGN1/2/3/4 (Acetyl Lys27/K33/K31)
来源
Polyclonal, Rabbit,IgG
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:1000-2000 ELISA 1:5000-20000
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
浓度
1 mg/ml
背景(Background)
The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMG17, the encoded protein may help maintain an open chromatin configuration around transcribable genes. [provided by RefSeq, Aug 2011],
功能
function:Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in an unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2.,mass spectrometry: PubMed:10739259,PTM:Phosphorylation on Ser-21 and Ser-25 weakens binding to nucleosomes and increases the rate of H3 phosphorylation (By similarity). Phosphorylation favors cytoplasmic localization.,RNA editing:Partially edited. A new initiator methionine may be created by a single uridine insertion in the 5'-UTR, causing an N-terminal extension of 45 amino acids. The existence of the RNA edited version is supported by direct protein sequencing by MS/MS of the following peptides specific to that version: 23-31 and 40-48. The RNA edited version is
基因名称(Gene Name)
HMGN1 HMG14
蛋白名称
HMGN1/2/3/4 (Acetyl Lys27/K33/K31)
简称
HMGN1/2/3/4
其他名称
Non-histone chromosomal protein HMG-14 (High mobility group nucleosome-binding domain-containing protein 1)
Fields
人基因ID
3150
人蛋白质序列数据库
P05114/P05204/Q15651/O00479
小鼠基因ID
100044391
小鼠蛋白质序列数据库
P18608
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Nucleus. Cytoplasm. Cytoplasmic enrichment upon phosphorylation. The RNA edited version localizes to the nucleus.
组织表达
储存(Storage)
-20°C/1 year

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HMGN1/2/3/4 (Acetyl Lys27/K33/K31) rabbit pAb

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