免疫原
The antiserum was produced against synthesized peptide derived from human SYT13. AA range:321-370
特异性
Synaptotagmin XIII Polyclonal Antibody detects endogenous levels of Synaptotagmin XIII protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
synaptotagmin 13(SYT13) Homo sapiens This gene encodes a member of the large synaptotagmin protein family. Family members have an extracellular N-terminal transmembrane domain and a cytoplasmic C terminus with two tandem C2 domains (C2A and C2B). Synaptotogmin family members can form homo- and heteromeric complexes with each other. They also have different biochemical properties and developmental profiles, and patterns of tissue distribution. Synaptotagmins function as membrane traffickers in multicellular organisms. Two alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011],
功能
domain:The first C2 domain/C2A does not mediate Ca(2+)-dependent phospholipid binding.,domain:The second C2 domain/C2B domain binds phospholipids regardless of whether calcium is present.,function:May be involved in transport vesicle docking to the plasma membrane.,similarity:Belongs to the synaptotagmin family.,similarity:Contains 2 C2 domains.,subunit:Interacts with NRXN1.,tissue specificity:Expressed in brain, pancreas and kidney.,
其他名称
SYT13; KIAA1427; Synaptotagmin-13; Synaptotagmin XIII; SytXIII
细胞定位
Membrane ; Single-pass membrane protein .
组织表达
Expressed in brain, pancreas and kidney.
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