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Caspase12 Polyclonal Antibody

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BYab-00343

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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宿主
反应性
应用
WB;IHC;IF;ELISA
分子量(DA)
50kD
免疫原
The antiserum was produced against synthesized peptide derived from human Caspase12. AA range:50-99
特异性
Caspase12 Polyclonal Antibody detects endogenous levels of Caspase12 protein.
来源
Polyclonal, Rabbit,IgG
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度
1 mg/ml
背景(Background)
Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011],
功能
proteolysis, apoptosis, virus-infected cell apoptosis, ER-nuclear signaling pathway, response to unfolded protein, cell death, response to organic substance, regulation of cell death, programmed cell death, death, endoplasmic reticulum unfolded protein response, cellular response to stress, cellular response to unfolded protein, response to endoplasmic reticulum stress, regulation of apoptosis, regulation of programmed cell death, response to protein stimulus,apoptosis in response to endoplasmic reticulum stress,
基因名称(Gene Name)
CASP12
蛋白名称
caspase12
简称
Caspase-12
其他名称
CASP12; Inactive caspase-12; CASP-12
Fields
>>Protein processing in endoplasmic reticulum;>>Apoptosis;>>NOD-like receptor signaling pathway;>>Alzheimer disease;>>Amyotrophic lateral sclerosis;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Hepatitis B
人基因ID
120329
人蛋白质序列数据库
Q6UXS9
小鼠基因ID
小鼠蛋白质序列数据库
O08736
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
endoplasmic reticulum,IPAF inflammasome complex,NLRP3 inflammasome complex,AIM2 inflammasome complex,
组织表达
Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis.
储存(Storage)
-20°C/1 year

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Caspase12 Polyclonal Antibody

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