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XRCC4 Monoclonal Antibody(5C10)

说明书

BYab-00115

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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宿主
反应性
应用
WB;IHC;IF;IP
分子量(DA)
38kD
免疫原
Synthetic Peptide of XRCC4
特异性
The antibody detects endogenous XRCC4 proteins.
来源
Monoclonal, Mouse
组成(Formulation)
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
稀释比例
WB: 1:2000 IP:1:200 IF 1:200 IHC 1:50-300
纯化工艺(Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
浓度
背景(Background)
The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand breaks. This protein plays a role in both non-homologous end joining and the completion of V(D)J recombination. Mutations in this gene can cause short stature, microcephaly, and endocrine dysfunction (SSMED). Alternative splicing generates several transcript variants. [provided by RefSeq, Dec 2015],
功能
function:Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.,PTM:Monoubiquitinated.,PTM:Phosphorylated by PRKDC. The phosphorylation seems not to be necessary for binding to DNA. Phosphorylation by CK2 promotes interaction with APTX.,PTM:Sumoylation at Lys-210 is required for nuclear localization and recombination efficiency. Has no effect on ubiquitination.,similarity:Belongs to the XRCC4 family.,subunit:Homodimer and homotetramer in solution. The homodimer associates with LIG4, and the LIG4-XRCC4 complex associates in a DNA-dep
基因名称(Gene Name)
XRCC4
蛋白名称
DNA repair protein XRCC4
简称
XRCC4
其他名称
XRCC4; DNA repair protein XRCC4; X-ray repair cross-complementing protein 4
Fields
>>Non-homologous end-joining
人基因ID
7518
人蛋白质序列数据库
Q13426
小鼠基因ID
108138
小鼠蛋白质序列数据库
Q924T3
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Nucleus . Chromosome . Localizes to site of double-strand breaks. .; [Protein XRCC4, C-terminus]: Cytoplasm . Translocates from the nucleus to the cytoplasm following cleavage by caspase-3 (CASP3). .
组织表达
Widely expressed.
储存(Storage)
-20°C/1 year

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XRCC4 Monoclonal Antibody(5C10)

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