免疫原
Synthesized peptide derived from human PDE4A AA range:530-580
特异性
This antibody detects endogenous levels of PDE4A at Human, Mouse,Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. ; [Isoform 1]: Efficiently hydrolyzes cAMP. ; [Isoform 2]: Efficiently hydrolyzes cAMP. ; [Isoform 3]: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. ; [Isoform 4]: Efficiently hydrolyzes cAMP. ; [Isoform 6]: Efficiently hydrolyzes cAMP. ; [Isoform 7]: Efficiently hydrolyzes cAMP.
基因名称（Gene Name）
PDE4A DPDE2
蛋白名称
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46)
细胞定位
[Isoform 1]: Cytoplasm, perinuclear region .; [Isoform 2]: Cytoplasm, perinuclear region . Cell projection, ruffle membrane .; [Isoform 3]: Cytoplasm, cytosol .; [Isoform 4]: Membrane; Peripheral membrane protein . Isoform 4 has propensity for association with membranes. .; [Isoform 6]: Cytoplasm, perinuclear region .; [Isoform 7]: Cytoplasm, cytosol. Membrane; Peripheral membrane protein . Predominantly cytosolic. .
组织表达
[Isoform 1]: Expressed in lymphoid cell subsets including CD8-positive T cells and T-helper 2 cells. Expressed in dendritic cells. ; [Isoform 2]: Highly expressed in liver, stomach, testis, thyroid and adrenal glands and at a lower extent in placenta, kidney, pancreas, ovary, uterus and skin. Expressed in myeloid cell subsets including dendritic cells, monocytes, macrophages, eosino
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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