免疫原
Synthesized peptide derived from human Bassoon/BSN
特异性
This antibody detects endogenous levels of Bassoon/BSNat Human, Mouse,Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02%sodiumazide.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse antiserumby
affinity-chromatography using epitope-specific immunogen.
功能
Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) whichisthe place in the synapse where neurotransmitter is released . After synthesis,participates in the formation of Golgi-derived membranous organellestermedPiccolo-Bassoon transport vesicles (PTVs) that are transported alongaxonstosites of nascent synaptic contacts . At the presynaptic active zone, regulatesthespatial organization of synaptic vesicle cluster, the protein complexesthat
execute membrane fusion and compensatory endocytosis (By similarity). Functions also in processes other than assembly such as the regulationof
specific presynaptic protein ubiquitination by interacting with SIAH1or theregulation of presynaptic autophagy by associating with ATG5 (By similarity).Mediates also synapse to nucleus communication leading to reconfigurationofgene expression by associating with the transcrip
基因名称（Gene Name）
BSN KIAA0434 ZNF231
蛋白名称
Protein bassoon (Zinc finger protein 231)
细胞定位
Cytoplasm . Cell junction, synapse, presynaptic active zone . Cytoplasm, cytoskeleton . Cytoplasmic vesicle, secretory vesicle, synaptic vesiclemembrane; Peripheral membrane protein . In retina, is localized in the outer plexiformlayerat ribbon synapses formed by rods and cones but was absent frombasal synapticcontacts formed by cones. In the retinal inner plexiformlayer localizedtoconventional inhibitory GABAergic synapses, made by amacrinecells, but absentfrom
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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