免疫原
Synthesized peptide derived from human RBPMS
特异性
This antibody detects endogenous levels of RBPMS at Human, Mouse
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺(Immunogen)
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins . Binds to poly(A) RNA .
基因名称(Gene Name)
RBPMS HERMES
蛋白名称
RNA-binding protein with multiple splicing (RBP-MS) (Heart and RRM expressed sequence) (Hermes)
细胞定位
Nucleus . Cytoplasm . Cytoplasm, P-body . Translocates into cytoplasmic stress granules that probably correspond to P-bodies in response to oxidative stress. .
组织表达
Ubiquitously expressed, at various levels depending on the isoform and the tissue.
储存(Storage)
-15°C to -25°C/1 year(Do not lower than -25°C)