免疫原
Synthesized peptide derived from human Choline Kinase Alpha
特异性
This antibody detects endogenous levels of Choline Kinase Alpha at Human, Mouse,Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Plays a key role in phospholipid biosynthesis by catalyzing the phosphorylation of free choline to phosphocholine, the first step in phosphatidylcholine biosynthesis . Also phosphorylates ethanolamine, thereby contributing to phosphatidylethanolamine biosynthesis . Has higher activity with choline . May contribute to tumor cell growth . ; [Isoform 1]: This isoform plays a key role in lipolysis of lipid droplets following glucose deprivation . In response to glucose deprivation, phosphorylated by AMPK, promoting localization to lipid droplets . Phosphorylation is followed by acetylation by KAT5, leading to dissociation of the homodimer into a monomer . Monomeric CHKA isoform 1 is converted into a tyrosine-protein kinase, which phosphorylates lipid droplet structural proteins PLIN2 and PLIN3, leading to lipolysis of lipid droplets .
基因名称（Gene Name）
CHKA CHK CKI
蛋白名称
Choline kinase alpha (CK) (EC 2.7.1.32) (CHETK-alpha) (Ethanolamine kinase) (EK) (EC 2.7.1.82)
细胞定位
Cytoplasm, cytosol .; [Isoform 1]: Lipid droplet . Isoform 1 localizes to lipid droplets following phosphorylation by AMPK. .
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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