免疫原
Synthesized peptide derived from human VTCN1
特异性
This antibody detects endogenous levels of VTCN1 at Human, Mouse,Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
Subcellular Location：
Cell membrane ; Single-pass type I membrane protein . Expressed at the cell surface. A soluble form has also been detected. .
基因名称（Gene Name）
VTCN1 B7H4 UNQ659/PRO1291
蛋白名称
V-set domain-containing T-cell activation inhibitor 1 (B7h.5) (Immune costimulatory protein B7-H4) (Protein B7S1) (T-cell costimulatory molecule B7x)
组织表达
Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis.
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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