免疫原
Synthesized peptide derived from human RBM39
特异性
This antibody detects endogenous levels of RBM39 at Human, Mouse
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺(Immunogen)
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
功能
RNA-binding protein that acts as a pre-mRNA splicing factor . Acts by promoting exon inclusion via regulation of exon cassette splicing . Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity (By similarity).
基因名称(Gene Name)
RBM39 HCC1 RNPC2
蛋白名称
RNA-binding protein 39 (Hepatocellular carcinoma protein 1) (RNA-binding motif protein 39) (RNA-binding region-containing protein 2) (Splicing factor HCC1)
细胞定位
Nucleus speckle . Concentrated in nuclear speckles (PubMed:8227358). Colocalizes with the core spliceosomal snRNP proteins (PubMed:8227358). .
组织表达
Widely expressed. Highly expressed in pancreas, skeletal muscle, lung and brain (PubMed:8227358). Expressed at intermediate level in kidney, liver and heart (PubMed:8227358).
储存(Storage)
-15°C to -25°C/1 year(Do not lower than -25°C)