免疫原
The antiserum was produced against synthesized peptide derived from human MaxiKalpha. AA range:721-770
特异性
MaxiKα Monoclonal Antibody detects endogenous levels of MaxiKα protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
potassium calcium-activated channel subfamily M alpha 1(KCNMA1) Homo sapiens MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],
功能
alternative products:May be partially controlled by hormonal stress. Additional isoforms seem to exist,disease:Defects in KCNMA1 are the cause of generalized epilepsy and paroxysmal dyskinesia (GEPD) [MIM:609446]. Epilepsy is one of the most common and debilitating neurological disorders. Paroxysmal dyskinesias are neurological disorders characterized by sudden, unpredictable, disabling attacks of involuntary movement often requiring life-long treatment. The coexistence of epilepsy and paroxysmal dyskinesia in the same individual or family is an increasingly recognized phenomenon. Patients manifest absence seizures, generalized tonic-clonic seizures, paroxysmal nonkinesigenic dyskinesia, involuntary dystonic or choreiform movements. Onset is usually in childhood and patients may have seizures only, dyskinesia only, or both.,domain:The calcium bowl constitutes one of the Ca(2+) sensors an
蛋白名称
Calcium-activated potassium channel subunit alpha-1
其他名称
KCNMA1; KCNMA; SLO; Calcium-activated potassium channel subunit alpha-1; BK channel; BKCA alpha; Calcium-activated potassium channel; subfamily M subunit alpha-1; K(VCA)alpha; KCa1.1; Maxi K channel; MaxiK; Slo-alpha; Slo1; Slowpoke homolog
Fields
>>cGMP-PKG signaling pathway;>>Vascular smooth muscle contraction;>>Insulin secretion;>>Renin secretion;>>Salivary secretion;>>Pancreatic secretion
细胞定位
Cell membrane ; Multi-pass membrane protein .
组织表达
Widely expressed. Except in myocytes, it is almost ubiquitously expressed.
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