免疫原
The antiserum was produced against synthesized peptide derived from human RASSF6. AA range:129-178
特异性
RASSF6 Monoclonal Antibody detects endogenous levels of RASSF6 protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a member of the Ras-association domain family (RASSF). Members of this family form the core of a highly conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH) pathway. The protein encoded by this gene is a Ras effector protein that induces apoptosis. A genomic region containing this gene has been linked to susceptibility to viral bronchiolitis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012],
功能
function:May act as a Ras effector protein.,sequence caution:Translated as Gln.,similarity:Contains 1 Ras-associating domain.,similarity:Contains 1 SARAH domain.,
蛋白名称
Ras association domain-containing protein 6
其他名称
RASSF6; Ras association domain-containing protein 6
Fields
>>Hippo signaling pathway;>>Hippo signaling pathway - multiple species
组织表达
Highest expression in thymus, kidney and placenta. Also detected in colon, small intestine and lung. Tends to be down-regulated in 30-60% of tumors derived from breast, colon, kidney liver, rectum, pancreas, stomach and the thyroid gland compared to the normal counterpart.
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