免疫原
The antiserum was produced against synthesized peptide derived from human GIMAP5. AA range:231-280
特异性
GIMAP5 Monoclonal Antibody detects endogenous levels of GIMAP5 protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene encodes an antiapoptotic protein that functions in T-cell survival. Polymorphisms in this gene are associated with systemic lupus erythematosus. Read-through transcription exists between this gene and the neighboring upstream GIMAP1 (GTPase, IMAP family member 1) gene. [provided by RefSeq, Dec 2010],
功能
function:Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence.,similarity:Belongs to the IAN GTP-binding protein family.,tissue specificity:Widely expressed with high levels in lymph node and spleen. High expression found in CD4 and CD8-positive T-cells and monocytes with very low levels in B-lymphocytes. Highly expressed in B-lymphocyte-derived neoplasms.,
蛋白名称
GTPase IMAP family member 5
其他名称
GIMAP5; IAN4L1; IAN5; IMAP3; GTPase IMAP family member 5; Immunity-associated nucleotide 4-like 1 protein; Immunity-associated nucleotide 5 protein; IAN-5; hIAN5; Immunity-associated protein 3
细胞定位
Lysosome membrane ; Single-pass type IV membrane protein . Endosome, multivesicular body membrane ; Single-pass type IV membrane protein . Endosome membrane ; Single-pass type IV membrane protein . The mitochondrial localization originally reported was observed with C-terminally tagged protein and was not confirmed in later publications. .
组织表达
Widely expressed with high levels in lymph node and spleen (PubMed:14724691). High expression found in T lymphocytes, including CD4 and CD8-positive T-cells, and monocytes (PubMed:14724691, PubMed:29382851). Very low expression levels in B-lymphocytes (PubMed:14724691).
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