免疫原
The antiserum was produced against synthesized peptide derived from human RHG9. AA range:220-269
特异性
ARHGAP9 Monoclonal Antibody detects endogenous levels of ARHGAP9 protein.
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺(Immunogen)
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景(Background)
This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards several Rho-family GTPases in vitro, converting them to an inactive GDP-bound state. It is implicated in regulating adhesion of hematopoietic cells to the extracellular matrix. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
功能
function:GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix.,similarity:Contains 1 PH domain.,similarity:Contains 1 Rho-GAP domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 1 WW domain.,tissue specificity:Predominantly expressed in peripheral blood leukocytes, spleen, and thymus.,
蛋白名称
Rho GTPase-activating protein 9
其他名称
ARHGAP9; Rho GTPase-activating protein 9; Rho-type GTPase-activating protein 9
组织表达
Predominantly expressed in peripheral blood leukocytes, spleen, and thymus.