免疫原
Synthesized peptide derived from the Internal region of human IRAK-2.
特异性
IRAK-2 Monoclonal Antibody detects endogenous levels of IRAK-2 protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kapMAB. [provided by RefSeq, Jul 2008],
功能
caution:Asn-335 is present instead of the conserved Asp which is expected to be an active site residue. This enzyme has been shown to be catalytically inactive.,domain:The protein kinase domain is predicted to be catalytically inactive.,function:Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.,similarity:Contains 1 death domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1.,tissue specificity:Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leuko
蛋白名称
Interleukin-1 receptor-associated kinase-like 2
其他名称
IRAK2; Interleukin-1 receptor-associated kinase-like 2; IRAK-2
Fields
>>Neurotrophin signaling pathway;>>Tuberculosis
细胞定位
nucleus,cytoplasm,cytosol,plasma membrane,endosome membrane,
组织表达
Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukocytes.
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