免疫原
The antiserum was produced against synthesized peptide derived from human ADK. AA range:1-50
特异性
ADK Monoclonal Antibody detects endogenous levels of ADK protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011],
功能
catalytic activity:ATP + adenosine = ADP + AMP.,cofactor:Binds 3 magnesium ions per subunit.,function:ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.,pathway:Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.,similarity:Belongs to the carbohydrate kinase pfkB family.,subunit:Monomer.,tissue specificity:Widely expressed. Highest level in placenta, liver, muscle and kidney.,
其他名称
ADK; Adenosine kinase; AK; Adenosine 5'-phosphotransferase
Fields
>>Purine metabolism;>>Metabolic pathways;>>Nucleotide metabolism
细胞定位
[Isoform 1]: Nucleus .; [Isoform 2]: Cytoplasm .
组织表达
Widely expressed. Highest level in placenta, liver, muscle and kidney.
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