免疫原
The antiserum was produced against synthesized peptide derived from human RELT. AA range:381-430
特异性
RELT Monoclonal Antibody detects endogenous levels of RELT protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kapMAB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is caMABle of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported. [provided by RefSeq, Jul 2008],
功能
function:Mediates activation of NF-kappa-B. May play a role in T-cell activation.,PTM:Phosphorylated in vitro by OXSR1.,similarity:Belongs to the RELT family.,similarity:Contains 1 TNFR-Cys repeat.,subunit:Associates with TRAF1. Interacts with RELL1, RELL2 and OXSR1.,tissue specificity:Highest levels are in spleen, lymph node, thymus, peripheral blood leukocytes, bone marrow and fetal liver. Very low levels in skeletal muscle, testis and colon. Not detected in brain, kidney and pancreas.,
蛋白名称
Tumor necrosis factor receptor superfamily member 19L
其他名称
RELT; TNFRSF19L; Tumor necrosis factor receptor superfamily member 19L; Receptor expressed in lymphoid tissues
Fields
>>Cytokine-cytokine receptor interaction
细胞定位
Cell membrane ; Single-pass type I membrane protein . Cytoplasm . Cytoplasm, perinuclear region .
组织表达
Spleen, lymph node, brain, breast and peripheral blood leukocytes (at protein level) (PubMed:28688764). Expressed highly in bone marrow and fetal liver. Very low levels in skeletal muscle, testis and colon. Not detected in kidney and pancreas.
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