免疫原
Synthesized peptide derived from human EAA2
特异性
This antibody detects endogenous levels of Human,Rat,Mouse EAA2
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景（Background）
This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Sep 2010],
功能
function:Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.,PTM:Glycosylated.,similarity:Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family.,subunit:Homotrimer. Interacts with JUB.,
基因名称（Gene Name）
SLC1A2 EAAT2 GLT1
其他名称
Excitatory amino acid transporter 2 (Glutamate/aspartate transporter II;Sodium-dependent glutamate/aspartate transporter 2;Solute carrier family 1 member 2)
Fields
>>Synaptic vesicle cycle;>>Glutamatergic synapse;>>Amyotrophic lateral sclerosis;>>Huntington disease
细胞定位
Cell membrane ; Multi-pass membrane protein .
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