免疫原
Synthesized phosho peptide around human CARD11 (Ser652)
特异性
This antibody detects endogenous levels of Human Mouse Rat CARD11 (phospho-Ser652)
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景（Background）
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kapMAB activation. When expressed in cells, this protein activated NF-kapMAB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008],
功能
caution:Supposed to contain a SH3 domain which is not detected by PROSITE, Pfam or SMART.,function:Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.,similarity:Contains 1 CARD domain.,similarity:Contains 1 guanylate kinase-like domain.,similarity:Contains 1 PDZ (DHR) domain.,subunit:CARD11 and BCL10 bind to each other by CARD-CARD interaction.,tissue specificity:Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLa S3, Molt-4, A549 and G431 cells.,
基因名称（Gene Name）
CARD11 CARMA1
其他名称
Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 1) (Carma 1)
Fields
>>NF-kappa B signaling pathway;>>T cell receptor signaling pathway;>>B cell receptor signaling pathway
细胞定位
Cytoplasm . Membrane raft . Colocalized with DPP4 in membrane rafts. .
组织表达
Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K-562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLaS3, MOLT-4, A-549 and G431 cells.
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