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MTMRC mouse mAb

BYmab-12399

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3个工作日

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宿主
反应性
应用
WB
分子量(DA)
免疫原
Synthesized peptide derived from human MTMRC AA range: 523-573
特异性
This antibody detects endogenous levels of MTMRC at Human/Mouse/Rat
来源
Monoclonal, Mouse,IgG
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-2000
纯化工艺(Immunogen)
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
浓度
1 mg/ml
背景(Background)
Phosphatidylinositide 3-kinase-derived membrane-anchored phosphatidylinositides, such as phosphatidylinositol 3-phosphate (PtdIns(3)P), regulate diverse cellular processes. The protein encoded by this gene functions as an adaptor subunit in a complex with an active PtdIns(3)P 3-phosphatase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014],
功能
caution:Lacks the phosphocysteine intermediate Cys active site in position 391 that is replaced by a Glu residue, preventing the hydrolase activity.,function:Inactive phosphatase that plays a role as an adapter for the phosphatase myotubularin to regulate myotubularin intracellular location.,miscellaneous:Catalytically inactive phosphatase.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.,similarity:Contains 1 myotubularin phosphatase domain.,subcellular location:Localizes to punctate vesicles when associated with MTM1.,subunit:Interacts with myotubularin MTM1 and myotubularin-related MTMR2.,tissue specificity:Ubiquitous with prominent expression in brain, heart, kidney, placenta, and lung.,
基因名称(Gene Name)
MTMR12 KIAA1682 PIP3AP
蛋白名称
MTMRC
简称
MTMRC
其他名称
Fields
人基因ID
人蛋白质序列数据库
小鼠基因ID
小鼠蛋白质序列数据库
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Cytoplasm . Sarcoplasmic reticulum . Cytoplasm, myofibril, sarcomere . Localizes to punctate vesicles when associated with MTM1 (PubMed:12847286). Localizes to triads, a structure formed by a T tubule and two sarcoplasmic reticulum terminal cisterna (By similarity). In skeletal muscles, co-localizes with MTM1 in the sarcomere (By similarity). Partially localizes to the sarcoplasmic reticulum in skeletal muscles (By similarity). .
组织表达
Expressed in skeletal muscles (at protein level) (PubMed:23818870). Ubiquitous with prominent expression in brain, heart, kidney, placenta, and lung (PubMed:11504939).
储存(Storage)
-20°C/1 year

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MTMRC mouse mAb

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