免疫原
Synthesized peptide derived from human CASC3 AA range: 434-484
特异性
This antibody detects endogenous levels of CASC3 at Human/Mouse/Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景（Background）
The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles. [provided by RefSeq, Jul 2008],
功能
domain:The coiled coil domain may be involved in oligomerization.,function:Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport.,PTM:Phosphorylated.,subcellular location:Predominantly found in the perinuclear region (By similarity). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner.,subunit:Interacts with STAU in an RNA-dependent manner (By similarity). Forms homo-oligomers.,tissue specificity:Widely expressed. Overexpressed in breast cancers and metastasis, as well as in gastric cancers.,
基因名称（Gene Name）
CASC3 MLN51
Fields
>>Nucleocytoplasmic transport;>>mRNA surveillance pathway
细胞定位
Cytoplasm . Cytoplasm, perinuclear region . Nucleus . Nucleus speckle . Cytoplasm, Stress granule . Cytoplasm, Cytoplasmic ribonucleoprotein granule . Cell projection, dendrite . Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner. Transported to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA (PubMed:15166247). In nuclear speckles, colocalizes with MAGOH. Under stress conditions, colocalizes with FMR1 and TIA1, but not MAGOH and RBM8A EJC core factors, in cytoplasmic stress granules (PubMed:17652158). In the dendrites of hippocampal neurons, localizes to dendritic ribonucleoprotein granules (By similarity). .
组织表达
Widely expressed. Overexpressed in breast cancers and metastasis, as well as in gastric cancers.
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