免疫原
Synthesized peptide derived from part region of human protein
特异性
PROF1 Monoclonal Antibody detects endogenous levels of protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1. [provided by RefSeq, Jul 2012],
功能
function:Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.,similarity:Belongs to the profilin family.,subunit:Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio. Found in a complex with XPO6, Ran, ACTB and PFN1.,
蛋白名称
Profilin-1 (Epididymis tissue protein Li 184a) (Profilin I)
Fields
>>Rap1 signaling pathway;>>Regulation of actin cytoskeleton;>>Amyotrophic lateral sclerosis;>>Shigellosis;>>Salmonella infection
细胞定位
Cytoplasm, cytoskeleton.
组织表达
Expressed in epididymis (at protein level).
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