免疫原
Synthesized peptide derived from human protein . at AA range: 250-330
特异性
MRGX2 Monoclonal Antibody detects endogenous levels of protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
function:Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled.,similarity:Belongs to the G-protein coupled receptor 1 family. Mas subfamily.,tissue specificity:Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion.,
功能
function:Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled.,similarity:Belongs to the G-protein coupled receptor 1 family. Mas subfamily.,tissue specificity:Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion.,
基因名称（Gene Name）
MRGPRX2 MRGX2
蛋白名称
Mas-related G-protein coupled receptor member X2
细胞定位
Cell membrane; Multi-pass membrane protein .
组织表达
Mainly expressed in mast cells. Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion (PubMed:12915402). Detected in blood vessels, scattered lymphocytes, and gastrointestinal ganglia (at protein level) (PubMed:16161007).
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