免疫原
Synthesized peptide derived from human protein . at AA range: 111-160
特异性
NIPA1 Monoclonal Antibody detects endogenous levels of protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a magnesium transporter that associates with early endosomes and the cell surface in a variety of neuronal and epithelial cells. This protein may play a role in nervous system development and maintenance. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with autosomal dominant spastic paraplegia 6. [provided by RefSeq, Nov 2008],
功能
disease:Defects in NIPA1 are the cause of spastic paraplegia autosomal dominant type 6 (SPG6) [MIM:600363]. Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.,sequence caution:Contaminating sequence. Sequence of unknown origin in the N-terminal part.,similarity:Belongs to the NIPA family.,tissue specificity:Widely expressed with highest levels in neuronal tissues.,
基因名称（Gene Name）
NIPA1 SPG6
蛋白名称
Magnesium transporter NIPA1 (Non-imprinted in Prader-Willi/Angelman syndrome region protein 1) (Spastic paraplegia 6 protein)
细胞定位
Cell membrane ; Multi-pass membrane protein . Early endosome . Recruited to the cell membrane in response to low extracellular magnesium. .
组织表达
Widely expressed with highest levels in neuronal tissues.
联系我们
关注我们
您当前的位置： 
成功添加到购物车
