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LGMN Monoclonal Antibody

BYmab-07239

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3个工作日

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宿主
反应性
应用
WB
分子量(DA)
47kD
免疫原
Synthesized peptide derived from human protein . at AA range: 60-140
特异性
LGMN Monoclonal Antibody detects endogenous levels of protein.
来源
Monoclonal, Mouse,IgG
组成(Formulation)
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
WB 1:500-2000
纯化工艺(Immunogen)
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
浓度
1 mg/ml
背景(Background)
This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008],
功能
catalytic activity:Hydrolysis of proteins and small molecule substrates at -Asn-|-Xaa- bonds.,function:Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.,PTM:Glycosylated.,similarity:Belongs to the peptidase C13 family.,tissue specificity:Ubiquitous. Particularly abundant in kidney, heart and placenta.,
基因名称(Gene Name)
LGMN PRSC1
蛋白名称
Legumain (EC 3.4.22.34) (Asparaginyl endopeptidase) (Protease, cysteine 1)
简称
LGMN
其他名称
Fields
>>Lysosome;>>Antigen processing and presentation
人基因ID
人蛋白质序列数据库
小鼠基因ID
小鼠蛋白质序列数据库
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Lysosome .
组织表达
Ubiquitous. Particularly abundant in kidney, heart and placenta.
储存(Storage)
-20°C/1 year

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LGMN Monoclonal Antibody

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