免疫原
Synthesized peptide derived from part region of human protein
特异性
DSCAM Monoclonal Antibody detects endogenous levels of protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene is a member of the immunoglobulin superfamily of cell adhesion molecules (Ig-CAMs), and is involved in human central and peripheral nervous system development. This gene is a candidate for Down syndrome and congenital heart disease (DSCHD). A gene encoding a similar Ig-CAM protein is located on chromosome 11. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012],
功能
function:Cell adhesion molecule that can mediate cation-independent homophilic binding activity. Could be involved in nervous system development.,similarity:Contains 10 Ig-like C2-type (immunoglobulin-like) domains.,similarity:Contains 6 fibronectin type-III domains.,tissue specificity:Primarily expressed in brain.,
蛋白名称
Down syndrome cell adhesion molecule (CHD2)
细胞定位
[Isoform Short]: Secreted .; [Isoform Long]: Cell membrane ; Single-pass type I membrane protein . Cell projection, axon . Cell projection, dendrite . Cell projection, growth cone . Cell junction, synapse . Localized in the soma, cell membrane, axon and growth cone of dissociated commissural axons. .
组织表达
Primarily expressed in brain.
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