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DOCK7 Monoclonal Antibody

BYmab-05510

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3个工作日

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宿主
反应性
应用
WB
分子量(DA)
235kD
免疫原
Synthesized peptide derived from part region of human protein
特异性
DOCK7 Monoclonal Antibody detects endogenous levels of protein.
来源
Monoclonal, Mouse,IgG
组成(Formulation)
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
WB 1:500-2000
纯化工艺(Immunogen)
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
浓度
1 mg/ml
背景(Background)
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that plays a role in axon formation and neuronal polarization. The encoded protein displays GEF activity toward RAC1 and RAC3 Rho small GTPases but not toward CDC42. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012],
功能
domain:The DHR-2 domain mediates GEF activity.,function:Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization.,similarity:Belongs to the DOCK family.,similarity:Contains 1 DHR-1 (CZH-1) domain.,similarity:Contains 1 DHR-2 (CZH-2) domain.,subcellular location:Enriched in the developing axons of hippocampal neurons.,subunit:Interacts with TSC1. Interacts with nucleotide-free RAC1 and RAC3.,tissue specificity:Widely expressed.,
基因名称(Gene Name)
DOCK7 KIAA1771
蛋白名称
Dedicator of cytokinesis protein 7
简称
DOCK7
其他名称
Fields
人基因ID
人蛋白质序列数据库
小鼠基因ID
小鼠蛋白质序列数据库
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Cell projection, axon . Enriched in the developing axons of hippocampal neurons.
组织表达
Widely expressed.
储存(Storage)
-20°C/1 year

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DOCK7 Monoclonal Antibody

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