免疫原
Synthesized peptide derived from part region of human protein
特异性
PDE1B Monoclonal Antibody detects endogenous levels of protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011],
功能
catalytic activity:Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.,enzyme regulation:Type I PDE are activated by the binding of calmodulin in the presence of Ca(2+).,function:Has a preference for cGMP as a substrate.,similarity:Belongs to the cyclic nucleotide phosphodiesterase family.,subunit:Homodimer.,
基因名称（Gene Name）
PDE1B PDE1B1 PDES1B
蛋白名称
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Cam-PDE 1B) (EC 3.1.4.17) (63 kDa Cam-PDE)
Fields
>>Purine metabolism;>>Metabolic pathways;>>Calcium signaling pathway;>>Olfactory transduction;>>Taste transduction;>>Renin secretion;>>Morphine addiction
细胞定位
Cytoplasm, cytosol .
组织表达
Brain,Human uterus,Testis,
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