免疫原
The antiserum was produced against synthesized peptide derived from the C-terminal region of human PPID. AA range:321-370
特异性
Cyclophilin D Monoclonal Antibody detects endogenous levels of Cyclophilin D protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein has been shown to possess PPIase activity and, similar to other family members, can bind to the immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008],
功能
catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,enzyme regulation:Less sensitive to inhibition by cyclosporin A than is CYP-18.,function:PPIases accelerate the folding of proteins.,function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.,online information:Cyclophilin entry,similarity:Belongs to the cyclophilin-type PPIase family.,similarity:Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.,similarity:Contains 1 PPIase cyclophilin-type domain.,similarity:Contains 3 TPR repeats.,subunit:Binds ESR1.,tissue specificity:Widely expressed.,
蛋白名称
Peptidyl-prolyl cis-trans isomerase D
其他名称
PPID; CYP40; CYPD; Peptidyl-prolyl cis-trans isomerase D; PPIase D; 40 kDa peptidyl-prolyl cis-trans isomerase; Cyclophilin-40; CYP-40; Cyclophilin-related protein; Rotamase D
Fields
>>Necroptosis;>>Cellular senescence;>>Alzheimer disease;>>Pathways of neurodegeneration - multiple diseases;>>Shigellosis
细胞定位
Cytoplasm . Nucleus, nucleolus . Nucleus, nucleoplasm .
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