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RUFY1 Monoclonal Antibody

BYmab-04183

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3个工作日

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宿主
反应性
应用
WB
分子量(DA)
80kD
免疫原
The antiserum was produced against synthesized peptide derived from human RUFY1. AA range:139-188
特异性
RUFY1 Monoclonal Antibody detects endogenous levels of RUFY1 protein.
来源
Monoclonal, Mouse,IgG
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-2000
纯化工艺(Immunogen)
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
浓度
1 mg/ml
背景(Background)
RUN and FYVE domain containing 1(RUFY1) Homo sapiens This gene encodes a protein that contains a RUN domain and a FYVE-type zinc finger domain. The encoded protein binds to phosphatidylinositol-3-phosphate (PI3P) and plays a role in early endosomal trafficking, tethering and fusion through interactions with small GTPases including Rab4, Rab5 and Rab14. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011],
功能
domain:The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate.,function:Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,PTM:Phosphorylation on Tyr-389 and/or Tyr-400 is required for interaction with BMX and endosomal targeting.,similarity:Contains 1 FYVE-type zinc finger.,similarity:Contains 1 RUN domain.,subunit:Interacts with BMX. May interact with SSB. Interacts with RAB4 and RAB5 that have been activated by GTP-binding.,tissue specificity:Broadly expressed, with highest levels in lung, testis, kidney and brain.,
基因名称(Gene Name)
RUFY1
蛋白名称
RUN and FYVE domain-containing protein 1
简称
RUFY1
其他名称
RUFY1; RABIP4; ZFYVE12; RUN and FYVE domain-containing protein 1; FYVE-finger protein EIP1; La-binding protein 1; Rab4-interacting protein; Zinc finger FYVE domain-containing protein 12
Fields
>>Endocytosis
人基因ID
人蛋白质序列数据库
小鼠基因ID
小鼠蛋白质序列数据库
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Cytoplasm. Early endosome membrane; Peripheral membrane protein.
组织表达
Broadly expressed, with highest levels in lung, testis, kidney and brain.
储存(Storage)
-20°C/1 year

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RUFY1 Monoclonal Antibody

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