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Ribosomal Protein L5 Monoclonal Antibody

BYmab-04150

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3个工作日

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宿主
反应性
应用
WB
分子量(DA)
34kD
免疫原
The antiserum was produced against synthesized peptide derived from human RPL5. AA range:161-210
特异性
Ribosomal Protein L5 Monoclonal Antibody detects endogenous levels of Ribosomal Protein L5 protein.
来源
Monoclonal, Mouse,IgG
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-2000
纯化工艺(Immunogen)
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
浓度
1 mg/ml
背景(Background)
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L18P family of ribosomal proteins. It is located in the cytoplasm. The protein binds 5S rRNA to form a stable complex called the 5S ribonucleoprotein particle (RNP), which is necessary for the transport of nonribosome-associated cytoplasmic 5S rRNA to the nucleolus for assembly into ribosomes. The protein interacts specifically with the beta subunit of casein kinase II. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found
功能
disease:Defects in RPL5 are the cause of Diamond-Blackfan anemia type 6 (DBA6) [MIM:612561]. DBA6 is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.,function:Required for rRNA maturation and formation of the 60S ribosomal subunits. This protein binds 5S RNA.,similarity:Belongs to the ribosomal protein L18P family.,
基因名称(Gene Name)
RPL5
蛋白名称
60S ribosomal protein L5
简称
Ribosomal Protein L5
其他名称
RPL5; MSTP030; 60S ribosomal protein L5
Fields
>>Ribosome;>>Coronavirus disease - COVID-19
人基因ID
人蛋白质序列数据库
小鼠基因ID
小鼠蛋白质序列数据库
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Cytoplasm . Nucleus, nucleolus .
组织表达
Aorta,Brain,Cervix carcinoma,Colon,Coronary arterial endothelium,Lung,Lymph,Testis,
储存(Storage)
-20°C/1 year

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Ribosomal Protein L5 Monoclonal Antibody

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