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Dok-6 Monoclonal Antibody

BYmab-03825

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3个工作日

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宿主
反应性
应用
WB
分子量(DA)
43kD
免疫原
The antiserum was produced against synthesized peptide derived from human DOK6. AA range:111-160
特异性
Dok-6 Monoclonal Antibody detects endogenous levels of Dok-6 protein.
来源
Monoclonal, Mouse,IgG
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-2000
纯化工艺(Immunogen)
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
浓度
1 mg/ml
背景(Background)
docking protein 6(DOK6) Homo sapiens DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).[supplied by OMIM, Mar 2008],
功能
domain:PTB domain mediates receptor interaction.,function:DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance.,PTM:On Ret activation, phosphorylated on one or more C-terminal tyrosine residues by an Src family kinase.,similarity:Belongs to the DOK family. Type B subfamily.,similarity:Contains 1 IRS-type PTB domain.,similarity:Contains 1 PH domain.,subunit:Interacts via its PTB domain with phosphorylated RET.,tissue specificity:Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis.,
基因名称(Gene Name)
DOK6
蛋白名称
Docking protein 6
简称
Dok-6
其他名称
DOK6; DOK5L; Docking protein 6; Downstream of tyrosine kinase 6
Fields
人基因ID
人蛋白质序列数据库
小鼠基因ID
小鼠蛋白质序列数据库
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
组织表达
Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis.
储存(Storage)
-20°C/1 year

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Dok-6 Monoclonal Antibody

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