免疫原
The antiserum was produced against synthesized peptide derived from human ARSK. AA range:481-530
特异性
Arylsulfatase K Monoclonal Antibody detects endogenous levels of Arylsulfatase K protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
Sulfatases (EC 3.1.5.6), such as ARSK, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008],
功能
cofactor:Binds 1 calcium ion per subunit.,PTM:The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.,similarity:Belongs to the sulfatase family.,
其他名称
ARSK; TSULF; Arylsulfatase K; ASK; Telethon sulfatase
细胞定位
Secreted . Lysosome .
组织表达
Expressed at high levels in the placenta and pancreas (PubMed:23986440). Expressed at intermediate levels in the lung, brain, heart, liver and kidney and at low levels in the muscle (PubMed:23986440).
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