免疫原
The antiserum was produced against synthesized peptide derived from human PIGX. AA range:183-232
特异性
PIG-X Monoclonal Antibody detects endogenous levels of PIG-X protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a type I transmembrane protein in the endoplasmic reticulum (ER). The protein is an essential component of glycosylphosphatidylinositol-mannosyltransferase I, which transfers the first of the four mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Studies in rat indicate that the protein is translated from a non-AUG translation initiation site. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009],
功能
function:Essential component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase PIGM.,pathway:Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.,PTM:N-glycosylated.,sequence caution:Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.,similarity:Belongs to the PIGX family.,subunit:Interacts with PIGM.,
蛋白名称
Phosphatidylinositol-glycan biosynthesis class X protein
其他名称
PIGX; Phosphatidylinositol-glycan biosynthesis class X protein; PIG-X
Fields
>>Glycosylphosphatidylinositol (GPI)-anchor biosynthesis;>>Metabolic pathways
细胞定位
Endoplasmic reticulum membrane ; Single-pass type I membrane protein .
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