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CYP24A1 Monoclonal Antibody

BYmab-02570

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3个工作日

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宿主
反应性
应用
WB
分子量(DA)
38kD
免疫原
The antiserum was produced against synthesized peptide derived from human Cytochrome P450 24A1. AA range:411-460
特异性
CYP24A1 Monoclonal Antibody detects endogenous levels of CYP24A1 protein.
来源
Monoclonal, Mouse,IgG
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-2000
纯化工艺(Immunogen)
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
浓度
1 mg/ml
背景(Background)
cytochrome P450 family 24 subfamily A member 1(CYP24A1) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
功能
catalytic activity:Calcidiol + NADPH + O(2) = secalciferol + NADP(+) + H(2)O.,catalytic activity:Calcitriol + NADPH + O(2) = calcitetrol + NADP(+) + H(2)O.,cofactor:Heme group.,function:Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23-hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product.,similarity:Belongs to the cytochrome P450 family.,
基因名称(Gene Name)
CYP24A1
蛋白名称
1,25-dihydroxyvitamin D(3) 24-hydroxylase mitochondrial
简称
CYP24A1
其他名称
CYP24A1; CYP24; 1; 25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; 24-OHase; Vitamin D(3) 24-hydroxylase; Cytochrome P450 24A1; Cytochrome P450-CC24
Fields
>>Steroid biosynthesis;>>Metabolic pathways;>>Parathyroid hormone synthesis, secretion and action;>>MicroRNAs in cancer
人基因ID
人蛋白质序列数据库
小鼠基因ID
小鼠蛋白质序列数据库
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Mitochondrion .
组织表达
PCR rescued clones,
储存(Storage)
-20°C/1 year

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CYP24A1 Monoclonal Antibody

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