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KCNK9 (TASK-3) Monoclonal Antibody

BYmab-01202

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3个工作日

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宿主
反应性
应用
WB
分子量(DA)
42kD
免疫原
Synthetic Peptide of KCNK9 (TASK-3) AA range: 220-270
特异性
KCNK9(TASK-3) protein(A239) detects endogenous levels of KCNK9(TASK-3)
来源
Monoclonal, Mouse,IgG
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-2000
纯化工艺(Immunogen)
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using specific immunogen.
浓度
1 mg/ml
背景(Background)
This gene encodes a protein that contains multiple transmembrane regions and two pore-forming P domains and functions as a pH-dependent potassium channel. Amplification and overexpression of this gene have been observed in several types of human carcinomas. This gene is imprinted in the brain, with preferential expression from the maternal allele. A mutation in this gene was associated with Birk-Barel mental retardation dysmorphism syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013],
功能
disease:Defects in KCNK9 may be the cause of a syndrome of mental retardation, hypotonia, and facial dysmorphism; also known as Birk Barel syndrome.,disease:Overexpressed in a high proportion of breast cancers. May confer resistance to growth factor deprivation and hypoxia, thereby promoting tumor cell survival in poorly oxygenated areas of solid tumors.,function:pH-dependent, voltage-insensitive, background potassium channel protein.,miscellaneous:Inhibited by phorbol 12-myristate 13-acetate (PMA). TASK-3 current is strongly decreased in the presence of an extracellular pH inferior to 7.0.,similarity:Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.,tissue specificity:Mainly found in the cerebellum. Also found in adrenal gland, kidney and lung.,
基因名称(Gene Name)
KCNK9
蛋白名称
Potassium channel subfamily K member 9 (Acid-sensitive potassium channel protein TASK-3) (TWIK-related acid-sensitive K(+) channel 3) (Two pore potassium channel KT3.2) (Two pore K(+) channel KT3.2)
简称
KCNK9
其他名称
Potassium channel subfamily K member 9 (Acid-sensitive potassium channel protein TASK-3;TWIK-related acid-sensitive K(+) channel 3;Two pore potassium channel KT3.2;Two pore K(+) channel KT3.2)
Fields
>>Aldosterone synthesis and secretion
人基因ID
人蛋白质序列数据库
小鼠基因ID
小鼠蛋白质序列数据库
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Cell membrane ; Multi-pass membrane protein .
组织表达
Mainly found in the cerebellum. Also found in adrenal gland, kidney and lung.
储存(Storage)
-20°C/1 year

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KCNK9 (TASK-3) Monoclonal Antibody

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