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SOX-2 Monoclonal Antibody

BYmab-01022

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3个工作日

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宿主
反应性
应用
WB
分子量(DA)
34kD
免疫原
Purified recombinant fragment of human SOX-2 expressed in E. Coli.
特异性
SOX-2 Monoclonal Antibody detects endogenous levels of SOX-2 protein.
来源
Monoclonal, Mouse
组成(Formulation)
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
稀释比例
WB 1:500-2000
纯化工艺(Immunogen)
Affinity purification
浓度
背景(Background)
SRY-box 2(SOX2) Homo sapiens This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008],
功能
disease:Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:206900]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS3 is characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula.,function:Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.,online information:Sox2 entry,PTM:Sumoylation inhibits bin
基因名称(Gene Name)
SOX2
蛋白名称
Transcription factor SOX-2
简称
SOX-2
其他名称
SOX2; Transcription factor SOX-2
Fields
>>Hippo signaling pathway;>>Signaling pathways regulating pluripotency of stem cells
人基因ID
6657
人蛋白质序列数据库
P48431
小鼠基因ID
小鼠蛋白质序列数据库
P48432
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Nucleus speckle . Cytoplasm . Nucleus . Acetylation contributes to its nuclear localization and deacetylation by HDAC3 induces a cytoplasmic delocalization (By similarity). Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity). Colocalizes with SOX6 in speckles. Colocalizes with CAML in the nucleus (By similarity). Nuclear import is facilitated by XPO4, a protein that usually acts as a nuclear export signal receptor (By similarity). .
组织表达
Fetal brain,Lung,Retina,
储存(Storage)
-20°C/1 year

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SOX-2 Monoclonal Antibody

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