免疫原
Synthesized peptide derived from human DNA pol β (Acetyl Lys72)
特异性
This antibody detects endogenous levels of Human,Mouse,Rat DNA pol β (Acetyl Lys72)
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景（Background）
catalytic activity:Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).,cofactor:Binds 2 magnesium ions per subunit.,domain:Residues 239-252 form a flexible loop which appears to affect the polymerase fidelity.,function:Repair polymerase. Conducts "gap-filling" DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.,PTM:Methylation by PRMT6 stimulates the polymerase activity by enhancing DNA binding and processivity.,similarity:Belongs to the DNA polymerase type-X family.,subunit:Monomer.,
功能
DNA metabolic process, DNA replication, DNA-dependent DNA replication, DNA repair, base-excision repair, pyrimidine dimer repair, anti-apoptosis, response to DNA damage stimulus, cell death, regulation of cell death, death, cellular response to stress, regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death,negative regulation of programmed cell death, negative regulation of cell death,
蛋白名称
DNA pol β (Acetyl Lys72)
其他名称
DNA polymerase beta (EC 2.7.7.7;EC 4.2.99.-)
Fields
>>Base excision repair;>>Human T-cell leukemia virus 1 infection;>>Viral carcinogenesis
细胞定位
Nucleus. Cytoplasm. Cytoplasmic in normal conditions. Translocates to the nucleus following DNA damage.
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