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DNA pol β (Acetyl Lys72) mouse mAb

BYmab-00919

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3个工作日

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宿主
反应性
应用
WB
分子量(DA)
38kD
免疫原
Synthesized peptide derived from human DNA pol β (Acetyl Lys72)
特异性
This antibody detects endogenous levels of Human,Mouse,Rat DNA pol β (Acetyl Lys72)
来源
Monoclonal, Mouse,IgG
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-2000
纯化工艺(Immunogen)
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
浓度
1 mg/ml
背景(Background)
catalytic activity:Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).,cofactor:Binds 2 magnesium ions per subunit.,domain:Residues 239-252 form a flexible loop which appears to affect the polymerase fidelity.,function:Repair polymerase. Conducts "gap-filling" DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.,PTM:Methylation by PRMT6 stimulates the polymerase activity by enhancing DNA binding and processivity.,similarity:Belongs to the DNA polymerase type-X family.,subunit:Monomer.,
功能
DNA metabolic process, DNA replication, DNA-dependent DNA replication, DNA repair, base-excision repair, pyrimidine dimer repair, anti-apoptosis, response to DNA damage stimulus, cell death, regulation of cell death, death, cellular response to stress, regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death,negative regulation of programmed cell death, negative regulation of cell death,
基因名称(Gene Name)
POLB
蛋白名称
DNA pol β (Acetyl Lys72)
简称
DNA pol β
其他名称
DNA polymerase beta (EC 2.7.7.7;EC 4.2.99.-)
Fields
>>Base excision repair;>>Human T-cell leukemia virus 1 infection;>>Viral carcinogenesis
人基因ID
人蛋白质序列数据库
小鼠基因ID
小鼠蛋白质序列数据库
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Nucleus. Cytoplasm. Cytoplasmic in normal conditions. Translocates to the nucleus following DNA damage.
组织表达
储存(Storage)
-20°C/1 year

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DNA pol β (Acetyl Lys72) mouse mAb

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