免疫原
Synthesized peptide derived from human RPUSD4
特异性
This antibody detects endogenous levels of RPUSD4 at Human, Mouse,Rat
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of different mitochondrial RNA substrates . Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA) . This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome . As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA, controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation . Acts on position 39 in mitochondrial tRNA(Phe) . Also catalyzes pseudouridylation of mRNAs in nucleus: acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions . Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing .
蛋白名称
RNA pseudouridylate synthase domain-containing protein 4
细胞定位
Mitochondrion matrix . Nucleus . Cytoplasm . Mainly localizes to mitochondrion (PubMed:23435261, PubMed:27974379, PubMed:28082677). Localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly (PubMed:27974379, PubMed:28082677). Also found in nucleus and cytoplasm (PubMed:23435261). .
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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