免疫原
Synthesized peptide derived from human SPO11
特异性
This antibody detects endogenous levels of SPO11 at Human, Mouse
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2.
蛋白名称
Meiotic recombination protein SPO11 (Cancer/testis antigen 35) (CT35)
组织表达
Highly expressed in testis.
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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