免疫原
Synthesized peptide derived from human CNOT8
特异性
This antibody detects endogenous levels of CNOT8 at Human, Mouse
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity
基因名称（Gene Name）
CNOT8 CALIF POP2
蛋白名称
CCR4-NOT transcription complex subunit 8 (CAF1-like protein) (CALIFp) (CAF2) (CCR4-associated factor 8)
细胞定位
Cytoplasm . Nucleus .
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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